Hereditary Factor X (Stuart-Prower Factor) Deficiency

Hereditary coagulation factor X deficiency.

Stuart Prower factor (Factor X) deficiency is a rare hereditary autosomal recessive coagulation disorder. We have come across three cases in the course of last 20 years at our institute. These patients presented with prolonged bleeding after minor trauma, epistaxis, subcutaneous bluish black nodules and two of them presented with history of consanguinity in parents. Hematological findings in co...

Observations on the separate assessment of Prower-Stuart factor activities.

The activities of the Prower-Stuart factor in the first and second phase of thromboplastin production were separately assayed in 100 normal persons and 50 Dindevan-treated patients. It was found that in some of the subjects examined the two activities varied independently, and that some of the normal persons presented a partial deficiency of the factor. The implications of these findings are di...

A comparison of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor).

A comparison has been made of the electrophoretic behavior, chemical composition, amino-terminal sequence, and immunological properties of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor). Some immunological crossreactivity was found between the antibody to prothrombin and factor X although prothrombin and factor X differ substantially in amino-acid and carbohydrat...

Some biochemical and electrophoretic studies on purified prothrombin, factor VII (proconvertin) and factor X (Stuart).

S TUDIES of the chemical nature of prothrombin have indicated a glycoprotein structure.2 Data obtained on purified bovine prothrombin have shown the reducing sugar content to be approximately 5 per cent, based on a reference standard of galactose and mannose.35 Laki et al.5 reported a value of 6.5 per cent in terms of glucose, and 1.6 to 1.7 per cent hexosamine. Alexander6 and colleagues observ...

A Pregnant Woman with Factor V Deficiency